REVIEW ON NANOSPONGES IN CANCER THERAPY

Abstract

The development of recent colloidal, porous, microscopic mesh-like delivery systems, or nanosponges, with a size range of 1 m, provides regulated drug delivery at a specific spot in the majority of cancer treatments. Nanosponges have a crucial role to play in the controlled shipping of drugs. Numerous medications, both lipophilic and hydrophilic, may be placed into nanosponges for targeted drug administration and to increase the solubility and bioavailability of the same medication. Nanosponge are able to move freely across the entire frame until they interact with a specific target point, cling to the floor, and begin a controlled drug release. After the development of Nanosponges, issues caused by conventional drug delivery systems were solved. Nanosponges are multifunctional drug delivery systems that both increase treatment efficacy and lessen undesirable side effects. A breakthrough in the treatment of cancer has been made possible by the development of nanosponges (NSs), which are polymeric structures made of branching cyclodextrin (CD). The traditional medication delivery mechanism, which is employed in the treatment of most malignancies, is frequently insoluble and has negative side effects. Thus, energetic drugs that are trapped in complex polymers made of cyclodextrins are employed in nanosponges. Because of the drug's increased solubility, hydrophobic tablets may incorporate into NSs. In this review, we concentrated on providing a fundamental introduction to nanosponges. We also concluded their preparation techniques, polymers used, and characterization.